Erythropoietin is involved in angiogenesis in human primary melanoma
نویسندگان
چکیده
منابع مشابه
Erythropoietin/erythropoietin-receptor system is involved in angiogenesis in human hepatocellular carcinoma
AIMS To correlate microvascular density and erythropoietin (Epo)/Epo-receptor (EpoR) expression in endothelial and tumour cells with histopathological type in hepatocellular carcinoma (HCC). METHODS AND RESULTS Specimens of primary HCC obtained from 50 patients who had undergone curative hepatectomy were investigated immunohistochemically by using anti-CD31, anti-Epo and anti-EpoR antibodies....
متن کاملErythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma
AIMS Previous studies have shown that increased vascularity is associated with tumour progression in human neuroblastoma (NB). The involvement of erythropoietin (Epo) in tumour angiogenesis has also been reported. The aim of this study was to correlate microvascular density and Epo/Epo-receptor (EpoR) expression in endothelial and tumour cells to the clinical stage of NB. METHODS AND RESULTS ...
متن کاملErythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs.
The accumulating evidence that erythropoietin and erythropoietin receptor are expressed in various non-haematopoietic organs suggests that erythropoietin signalling might be involved in the growth of tumours, but this possibility has never been examined. We found that mRNAs for erythropoietin and erythropoietin receptor are expressed in malignant tumours of female reproductive organs, where ery...
متن کاملAngiogenesis and Progression in Human Melanoma
In tumor growth, angiogenesis, the process of new-formation of blood vessels from pre-existing ones, is uncontrolled and unlimited in time. The vascular phase is characterized by the new-formation of vascular channels that enhances tumor cell proliferation, local invasion and hematogenous metastasis. Human malignant melanoma is a highly metastatic tumor with poor prognosis, and high resistance ...
متن کاملCystathionine γ-lyase is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesis
Atherosclerotic plaques are classically divided into stable and vulnerable plaques. Vulnerable plaques are prone to rupture with a risk for infarction. High intraplaque microvessel density predisposes to plaque vulnerability. Hydrogen sulfide (H2S) is a proangiogenic gasotransmitter which is endogenously produced by cystathionine γ-lyase (CSE), and is believed to have vasculoprotective effects....
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2010
ISSN: 0959-9673
DOI: 10.1111/j.1365-2613.2010.00731.x